Planova™
Launched in 1989, Planova filters are the world's first filters developed specifically for removing viruses from biotherapeutic drug products such as biopharmaceuticals and plasma derivatives.
How Planova Filters Work
Planova filters contain a bundle of straw-like hollow fibers. When a protein solution with possible viral contamination is introduced into these hollow fibers, the solution penetrates the fiber wall and works its way to the outside of the fiber.
Within these walls, there is an intricate, three-dimensional network of interconnected void and capillary pores just nanometers in size. Viruses are thus filtered gradually and effectively, while proteins migrate outward with minimal adsorption and inactivation.
Size Exclusion
Planova virus removal works on the principle of size exclusion, unaffected by physical or chemical effects such as adsorption. Therefore, even unknown viruses can be excluded as long as the virus size meets the exclusion specification of the filter.
Wide range of Surface Areas with Excellent Scalability
The same type of housing, combined with the scaled number of hollow fibers in filters of different sizes, results in reliable scalability from lab-scale prototypes to large-scale manufacturing.