High Quality Filtrates

BioOptimal MF-SL can produce a high quality filtrate even from a feed solution with low cell viability and high turbidity. The graph below compares the turbidities of a filtrate produced by BioOptimal MF-SL and a filtrate produced by a competitor filter, both using feed solutions of CHO cells with cell densities of 1.48 × 10⁷
cells/mL, viabilities of 78.6%, and turbidities of 1600 NTU. The BioOptimal MF-SL filtrate clearly shows a much higher degree of clarity.

The very low filtrate turbidity provided by BioOptimal MF-SL contributes to the improvement of the next purification steps in the downstream process. The filtration capacity of a 0.22 μm sterile filter is much less affected by the BioOptimalMF-SL filtrate than the Microfilter A (flat sheet membrane) filtrate.