Planova filters are able to remove a variety of viruses ranging from HIV to parvovirus B19, which is among the smallest known viruses found in nature. Any virus -irrespective of whether or not it is of a currently known type- can be removed from protein solutions using Planova filters, provided that the size of the viruses is larger than the pore size rating of the Planova filters.
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Planova filters can be applied to a broad range of biotherapeutics, including human plasma-derived proteins, recombinant proteins, and monoclonal antibodies. The table lists typical examples of biologicals to which Planova filters have been applied for virus removal.
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During filtration of protein solutions, viruses are effectively removed yet proteins smoothly permeate the membrane, resulting in high recovery rates without adsorption or denaturation.
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Planova™ filters are assembled under strictly controlled conditions in a state-of-the-art plant conforming to in-house good manufacturing practice based on U.S. Food and Drug Administration cGMP.
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Planova filters have been included in more than 300 articles appearing in peer-reviewed scientific journals. Reprints of the literature shown below are available from Asahi Kasei Medical, and cover application, membrane structure and mechanism, as well as other topics.
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Instructions for Use are available for all Planova filters and Asahi Integrity Test Kits.
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