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Case Studies
In vitro study of a triple-secured von Willebrand factor concentrate
Mazurier, C., et al. (Laboratoire Français du Fractionnement et des Biotechnologies) Vox Sanguinis 86: 100-104 (2004).
Virus removal from hemoglobin solution using Planova Membrane
Naito, Y., et al. (Waseda University, Hokkaido Red Cross, and Tokyo Medical University) Journal of Artificial Organs 5: 141-145 (2002).
Inactivation and Clearance of Viruses During the Manufacture of High Purity Factor IX
Johnston, A., et al. (CSL Limited and Macfarlane Burnet Centre for Medical Research) Biologicals 28: 129-136 (2000).
Removal of Viruses from Human Intravenous Immune Globulin by 35 nm Nanofiltration
Troccoli, N., et al. (Massachusetts Biologic Laboratories and Biologic Research Faculty and Facility) Biologicals 26: 321-329 (1998).
Virus Removal Studies Using Nanofiltration Membranes<
O'Grady, J., et al. (MedImmune, Inc. and Biological Research Faculty and Facility) Dev Biol Stand. 88: 319-326 (1996).
Improved removal of viruslike particles from purified monoclonal antibody IgM preparation via virus filtration
Maerz, H., et al. (University of Leipzig, Humboldt-University/Charité, and Asahi Chemical Industry) Nature Biotechnology 14: 651-652 (1996).
Manufacturing process of Anti-thrombin III concentrate: viral safety validation studies and effect of column re-use on viral clearance
Morrica, A., et al. (Kedrion S.p.A. and Q-ONE Biotech Ltd) Biologicals 31: 165-173 (2003).
A new liquid intravenous immunoglobulin with three dedicated virus reduction steps: virus and prion reduction capacity
Poelsler, G., et al. (Baxter Bioscience) Vox Sanguinis 94: 184-192 (2008)
Large-scale production and properties of human plasma-derived activated Factor VII concentrate
Tomokiyo, K., et al. (Kaketsuken) Vox Sanguinis 84: 54-64 (2003).
Implementation of a 20-nm pore-size filter in the plasma-derived Factor VIII manufacturing process
Furuya, K., et al. (Japanese Red Cross Plasma Fraction Center) Vox Sanguinis 91: 119-125 (2006).
Viral safety of Nanogam®, a new 15 nm-filtered liquid immunoglobulin product
Terpstra, F., et al. (Sanquin and Finnish Red Cross Blood Service) Vox Sanguinis 90: 21-32 (2006).
A solvent/detergent-treated and 15-nm filtered factor VIII: a new safety standard for plasma-derived coagulation factor concentrates
Chtourou, S., et al. (LFB and NIBSC) Vox Sanguinis 92: 327-337 (2007).
Removal of small nonenveloped viruses by antibody-enhanced nanofiltration during the manufacture of plasma derivative
Kreil, T., et al. (Baxter BioScience) Transfusion 46: 1143-1151 (2006).
Clearance of dengue virus in the plasma-derived therapeutic proteins
Xie, Y., et al. (Advantek Serum Laboratories Limited and The Chinese University of Hong Kong) Transfusion 48: 1342-1347 (2008).
Development of a Highly Purified Multicomponent Leukocyte IFN-a Product
Tölö, H., et al. (Finnish Red Cross Blood Transfusion Service and Biomedical Center) Journal of Interferon and Cytokine Research 21: 913-920 (2001).
Nanofiltration of single plasma donations: feasibility study
Burnouf, T., et al. (Human Plasma Product Services, Asahi Kasei Corporation, El-Shabrawishy Blood Bank, Cairo University, and St Thomas' Hospital) Vox Sanguinis 84: 111-119 (2003).
A Two-Column Process to Purify Antibodies Without Protein A
Ferreira, G., et al. (Medarex, Inc.) BioPharm International (2007).
Virus Filtration of High-Concentration Monoclonal Antibody Solutions
Marques, B., et al. (Merck and Co., Inc.) Biotechnology Progress 25: 483-491 (2009).
Effect of Antibody Solution Conditions on Filter Performance for Virus Removal Filter Planova™ 20N
Hongo-Hirasaki, T., et al. (Asahi Kasei Medical Co., Ltd.) Biotechnology Progress 26: 1080-1087 (2010).
Effects of Varying Virus-Spiking Conditions on a Virus-Removal Filter Planova™ 20N in a Virus Validation Study of Antibody Solutions
Hongo-Hirasaki, T., et al. (Asahi Kasei Medical Co., Ltd.) Biotechnology Progress 27: 162-169 (2011).
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